After a disappointing 2024 season plagued by injuries and inconsistency, the San Francisco 49ers are aiming for redemption. With the NFL’s officially easiest schedule based on last year’s records, the 49ers have a prime opportunity to bounce back into playoff contention in 2025.
The Niners will play all 17 games domestically and have five primetime matchups, highlighting their status as one of the league’s most-watched teams.
49ers open their season with a divisional showdown
San Francisco kicks off the season with a tough Week 1 game on the road against the Seattle Seahawks. That sets the tone for early division matchups that will test whether this squad can recapture its 2023 playoff form.
Which teams will the 49ers face?
The Niners will take on opponents from the NFC West, NFC South, and AFC South, along with a few intra-conference games based on last year’s standings. Home games at Levi’s Stadium include high-interest matchups against the Rams, Bears, and Seahawks.
Notably, the 49ers avoid international travel this season — a possible advantage as they aim to stay fresh and focused throughout the year.
Full 2025 NFL schedule for the 49ers, week by week
- Week 1: at Seahawks
- Week 2: at Saints
- Week 3: vs. Cardinals
- Week 4: vs. Jaguars
- Week 5: at Rams (TNF)
- Week 6: at Buccaneers
- Week 7: vs. Falcons (SNF)
- Week 8: at Texans
- Week 9: at Giants
- Week 10: vs. Rams
- Week 11: at Cardinals
- Week 12: vs. Panthers (MNF)
- Week 13: at Browns
- Week 14: BYE
- Week 15: vs. Titans
- Week 16: at Colts (MNF)
- Week 17: vs. Bears (SNF)
- Week 18: vs. Seahawks
The bolded matchups mark the most anticipated games on the 49ers’ 2025 NFL schedule, as these bolded dates highlight key clashes that could define San Francisco’s season.
Breakdown of the 49ers’ 2025 NFL matchups, home and away
San Francisco’s 2025 opponents posted a league-low .415 winning percentage last year. While that suggests a manageable path to double-digit wins, past trends show strength-of-schedule projections don’t always translate to success. Health and cohesion will still be critical.
How to get 49ers tickets in 2025
Fans can buy official tickets for all home and away games at the official 49ers website. Primetime and late-season games like the home closer vs. Seattle are expected to be in high demand.
As the 49ers aim to bounce back in 2025, their favorable schedule offers a real chance to reclaim their spot among the NFL’s elite.